166882-70-8
中文名稱
166882-70-8
英文名稱
2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]-
CAS
166882-70-8
分子式
C19H21NO3S2
分子量
375.5
MOL 文件
166882-70-8.mol
166882-70-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10438 英文別名
ZD 4407AZD 4407
2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]-
物理化學(xué)性質(zhì)
沸點665.6±55.0 °C(Predicted)
密度1.38±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)13.68±0.40(Predicted)
常見問題列表
生物活性
AZD 4407 是一種有效的 5-脂氧合酶 (5-lipoxygenase) 抑制劑。靶點
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5-Lipoxygenase
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體外研究
In view of the powerful spasmogenic actions of leukotrienes in vascular and bronchial tissue, drugs which block their biosynthesis by inhibiting 5-lipoxygenase may have therapeutic potential in a variety of inflammatory conditions including inflammatory arthropothies, asthma, psoriasis, and inflammatory bowel disease. One such compound is AZD 4407 (ZD4407).