167467-53-0
中文名稱
化合物 BMS-186511
英文名稱
BMS 186511
CAS
167467-53-0
分子式
C34H60N3O7PS
分子量
685.89
MOL 文件
167467-53-0.mol
167467-53-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)917.3±65.0 °C(Predicted)
密度1.090±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)2.80±0.50(Predicted)
應(yīng)用領(lǐng)域
用途一
BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from malignant schwannoma of an NF1 patient. Following treatment with BMS-186511 , ST88-14 cells became flat, nonrefractile, were contact-inhibited, and lost their ability to grow in soft agar. BMS-186511 was found to specifically inhibit FT, but not geranylgeranyltransferase I, a closely related enzyme. Thus, it is conceivable that FT inhibitors may ultimately become the first generation of drugs against the malignant phenotype in NF1 based on rational insights into the mechanism of action of neurofibromin.