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1675-66-7

中文名稱 阿地米屈
英文名稱 AdelMitrol
CAS 1675-66-7
分子式 C13H26N2O4
分子量 274.36
MOL 文件 1675-66-7.mol
更新日期 2025/10/13 11:49:05
1675-66-7 結(jié)構(gòu)式 1675-66-7 結(jié)構(gòu)式

基本信息

中文別名
N1,N9-雙(2-羥乙基)壬二酰胺
英文別名
NSC 27132
AdelMitrol
AdelMitrol USP/EP/BP
N,N'-Bis(2-hydroxyethyl)nonanediamide
Nonanediamide, N1,N9-bis(2-hydroxyethyl)-
所屬類別
原料藥:皮膚科用藥

物理化學(xué)性質(zhì)

熔點(diǎn)132-134℃
沸點(diǎn)596.4±45.0 °C(Predicted)
密度1.097±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMSO:77.5(Max Conc. mg/mL);282.47(Max Conc. mM)
Ethanol:28.0(Max Conc. mg/mL);102.06(Max Conc. mM)
Water:55.0(Max Conc. mg/mL);200.47(Max Conc. mM)
酸度系數(shù)(pKa)14.19±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
InChIInChI=1S/C13H26N2O4/c16-10-8-14-12(18)6-4-2-1-3-5-7-13(19)15-9-11-17/h16-17H,1-11H2,(H,14,18)(H,15,19)
InChIKeyPAHZPHDAJQIETD-UHFFFAOYSA-N
SMILESC(NCCO)(=O)CCCCCCCC(NCCO)=O
阿地米屈價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-B1026R阿地米屈
Adelmidrol (Standard)
1675-66-75 mg300元
2026/06/05HY-B1026R阿地米屈
Adelmidrol (Standard)
1675-66-710 mg450元
2026/06/05HY-B1026R阿地米屈
Adelmidrol (Standard)
1675-66-725 mg800元

常見問題列表

生物活性
Adelmidrol是十六酰胺乙醇(PEA)的類似物,具有抗炎活性。
靶點(diǎn)

NF-κB

COX-2

PPARγ

體外研究

Adelmidrol is a palmitoylethanolamide analogue. Adelmidrol reduces NF-κB translocation, COX-2, and p-ERK expression; proinflammatory cytokine release; and the incidence of nitrotyrosine and poly(ADP)ribose in the colon.

體內(nèi)研究

Adelmidrol (10 mg/kg, o.s.) reduces significantly the degree and severity of the macroscopic and histologic signs of colon injury. Moreover, 4 days after colitis induced by dinitrobenzene sulfonic acid (DNBS) treatment, all mice have diarrhea and a reduction in body weight (compared with the sham groups). Adelmidrol (10 mg/kg, o.s.) treatment significantly reduces the loss of body weight. The inflammatory bowel disease (IBD) induced by DNBS intrarectally administered is also characterized by an augmentation in myeloperoxidase (MPO) activity, an indicator of neutrophil accumulating in the colon. This is consistent with light microscopic observations showing the colon of vehicle-treated DNBS mice to contain a large number of neutrophils. In contrast, Adelmidrol (10 mg/kg, o.s.) significantly reduces the degree of polymorphonuclear cell infiltration (determined as reduction in MPO activity) in inflamed colon.

"1675-66-7" 相關(guān)產(chǎn)品信息
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