1680204-90-3
1680204-90-3 結(jié)構(gòu)式
基本信息
中文別名
化合物CC618化合物CC618,10 MM DMSO 溶液
4-甲基-2-[4-(三氟甲基)苯基]-N-[2-[[5-(三氟甲基)-2-吡啶基]磺?；鵠乙基]乙基]-5-噻唑烷酰胺
英文別名
CC-6185-Thiazolecarboxamide, 4-methyl-2-[4-(trifluoromethyl)phenyl]-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-
物理化學(xué)性質(zhì)
密度1.466±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)9.39±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
CC618 is a potent and selective PPARβ/δ antagonist. CC618 selectively antagonizes agonist-induced PPARβ/δ activity with an IC50 = 10.0 μM. The treatment of PPARβ/δ with CC618 leads to a covalent modification of Cys249, located centrally in the PPARβ/δ ligand binding pocket, corresponding to the conversion of its thiol moiety to a 5-trifluoromethyl-2-pyridylthioether.