168682-53-9

中文名稱 EZATIOSTAT游離的

英文名稱 Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-

CAS 168682-53-9

分子式 C27H35N3O6S

分子量 529.65

MOL 文件 168682-53-9.mol

更新日期 2026/07/21 11:27:21

168682-53-9 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 EZATIOSTAT游離的價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

EZATIOSTAT游離
EZATIOSTAT游離的
GSTP1-1抑制劑(EZATIOSTAT)

英文別名

CS-1110
Ezatiostat
Terrapin 199
Ezatiostat, >96%
Ezatiostat, >=98%
TER199(free base)
Ezatiostat (TER199)
Ezatiostat TFA (free base)
TER 199
TLK-199
TELINTRA
(2R)-L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine 1,3-diethyl ester

所屬類別

生物化工：激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)>94°C (dec.)

沸點(diǎn)749.7±60.0 °C(Predicted)

密度1.216±0.06 g/cm3(Predicted)

儲(chǔ)存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度可溶于DMSO（少許）、甲醇（少許）

酸度系數(shù)(pKa)12?+-.0.46(Predicted)

形態(tài)固體

顏色白色至灰白色

InChIKeyFXTMNDVNPLUYKX-OKIYALLLNA-N

SMILESC(OCC)(=O)[C@@H](C1=CC=CC(CC)=C1)N(C(=O)CC[C@@H](C(O)=O)N)C(=O)[C@H](CSCC1=CC=CC=C1)N |&1:5,19,26,r|

安全數(shù)據(jù)

WGK GermanyWGK 3

存儲(chǔ)類別11 - Combustible Solids

圖譜信息

EZATIOSTAT游離的(168682-53-9)質(zhì)譜(MS)

EZATIOSTAT游離的價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/07/06	S9698	EZATIOSTAT游離的 Ezatiostat	168682-53-9	5mg	795.31元
2026/07/06	S9698	EZATIOSTAT游離的 Ezatiostat	168682-53-9	10mM (1mL in DMSO)	958.23元
2026/07/06	S9698	EZATIOSTAT游離的 Ezatiostat	168682-53-9	25mg	2375.42元

常見問題列表

生物活性

Ezatiostat (TER199, TLK199, Telintra) 是一種谷胱甘肽的三肽類似物，是 Glutathione S-transferase P1-1 (GSTP1-1) 的擬肽抑制劑。Ezatiostat 可激活 c-Jun NH2 terminal kinase (JNK1) 和 ERK1/ERK2 并誘導(dǎo)凋亡。

靶點(diǎn)

Target	Value
GSTP1-1 ()
JNK1 ()
ERK1/ERK2 ()

體外研究

Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone.
Selection of a resistant clone of an HL60 tumor cell line through chronic exposure to Ezatiostat (TLK199) results in cells with elevated activities of c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2, and allowes the cells to proliferate under stress conditions that induced high levels of apoptosis in the wild type cells.

體內(nèi)研究

Administration of Ezatiostat (TLK199), stimulates both lymphocyte production and bone marrow progenitor (colony-forming unit-granulocyte macrophage) proliferation, but only in glutathione S-transferase P1-1 (GSTP1 ^+/+ ) and not in GSTP1 ^-/- animals.