168705-70-2
中文名稱
化合物SY-640
英文名稱
Acetamide, N-(1,3-benzodioxol-5-ylmethyl)-N-methyl-
CAS
168705-70-2
分子式
C11H13NO3
分子量
207.23
MOL 文件
168705-70-2.mol
168705-70-2 結(jié)構(gòu)式
基本信息
中文別名
化合物SY-640 英文別名
Acetamide, N-(1,3-benzodioxol-5-ylmethyl)-N-methyl-Acetamide,inhibit,acnes,Propionibacterium,Endogenous Metabolite,hepatoprotective,Lipopolysaccharide,SY 640,SY640,Inhibitor,SY-640
物理化學(xué)性質(zhì)
熔點(diǎn)103 °C
沸點(diǎn)349.2±21.0 °C(Predicted)
密度1.213±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 100 mg/mL (482.56 mM)
酸度系數(shù)(pKa)-0.58±0.70(Predicted)
形態(tài)Liquid
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
SY-640 是乙酰胺衍生物，具有有效的保肝作用。SY-640 可減輕痤瘡丙酸桿菌和脂多糖誘導(dǎo)的小鼠肝損傷。靶點(diǎn)
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Human Endogenous Metabolite
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體外研究
SY-640 inhibits the number of liver-infiltrating cells and attenuates the increased expression of leukocyte function-associated antigen-1 on these cells.
體內(nèi)研究
SY-640 (Oral; 150 mg/kg; once daily for 7 days) significantly inhibits Propionibacterium acnes and Lipopolysaccharide-induced liver injury, but a single administration is without effect.
SY-640 (p.o.; 150 mg/kg; once daily for three days) significantly increases the liver microsomal cytochrome P-450 content and aminopyrine demethylase activity in mice. The hepatic microsomal aminopyrine demethylase activity is obviously inhibited two hours after oral administration of SY-640.