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17019-46-4

中文名稱 (2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol
英文名稱 (2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol
CAS 17019-46-4
分子式 C9H11N5O3
分子量 237.215
MOL 文件 17019-46-4.mol
17019-46-4 結(jié)構(gòu)式 17019-46-4 結(jié)構(gòu)式

基本信息

中文別名
化合物 T31672
英文別名
Erythrofuranosyladenine
9-β-D-Erythrofuranosyladenine
(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol

應(yīng)用領(lǐng)域

用途一
Erythrofuranosyladenine, also known as 9-beta-D-Erythrofuranosyladenine and ETA, is a nontoxic MTAP substrate. Erythrofuranosyladenine is an effective salvage agent for methylthioadenosine phosphorylase–selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. The cytotoxicity of EFA to hematopoietic progenitors erythroid burst-forming units (BFU-Es) and granulocyte-macrophage colony-forming units (CFU-GMs) was at least 26- to 41-fold less than that of MTA. EFA selectively rescued MTAP+ MOLT-4 cells from L-alanosine toxicity at 25 microM with negligible toxicity even at 100 microM. EFA is an effective agent for salvaging MTAP+ cells from L-alanosine toxicity and is superior to MTA due to lower cytotoxicity.
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