171543-83-2
中文名稱
ASP-ASP-PRO-PRO-LEU-SER-ILE-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-THR-LEU-LEU-GLU-LEU-ALA-ARG-THR-GLN-SER-GLN-ARG-GLU-ARG-ALA-GLU-GLN-ASN-ARG-ILE-ILE-PHE-ASP-SER-VAL
英文名稱
UROCORTIN (RAT)
CAS
171543-83-2
分子式
C206H338N62O64
分子量
4707.26
MOL 文件
171543-83-2.mol
更新日期
2026/07/07 17:20:43
171543-83-2 結構式
基本信息
中文別名
優(yōu)洛可定尾促皮質肽
英文別名
Rat urocortinUROCORTIN (RAT)
Urocortin 1 (rat)
Urocortin (sheep)
PubChem ID: 90479814
Urocortin ratUrocortin
UROCORTIN (RAT) (MOUSE)
Urocortin rat, ≥97% (HPLC)
UROCORTIN (RAT) (FREE ACID)
M.W. 4707.26 C206H338N62O64
物理化學性質
儲存條件-20°C
溶解度1% acetic acid: >1 mg/mL, clear, colorless
形態(tài)powder
顏色White to off-white
生物來源rat
水溶解性Soluble to 1 mg/ml in water
序列Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
常見問題列表
生物活性
Urocortin, rat (Urocortin (Rattus norvegicus)) 是一種神經肽，也是一種有效的內源性 CRFR 激動劑，對人 CRF1，大鼠 CRF2α 和小鼠 CRF2β 的 Ki 分別為 13 nM，1.5 nM 和 0.97 nM。靶點
Ki: 0.32 nM (hCRF1), 2.2 nM (rCRF2α), and 0.62 nM (mCRF2β)
體外研究
Urocortin, rat induces cyclic AMP (cAMP) generation with EC 50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF 1 , rat CRF 2α and mouse CRF 2β , respectively in stably transfected Chinese hamster ovary cells.
體內研究
Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior.