174689-39-5

中文名稱(chēng) 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE

英文名稱(chēng) 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE

CAS 174689-39-5

分子式 C23H29NO6

分子量 415.49

MOL 文件 174689-39-5.mol

更新日期 2026/06/01 07:47:33

174689-39-5 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

化合物SR59230A
(S)-1-(2-乙基苯氧基)-3-(((S)-1,2,3,4-四氫萘-1-基)氨基)丙-2-醇草酸鹽

英文別名

SR 59230A
SR59230AHCl
SR 59230A HYDROCHLORIDE
SR 59230A >=98% (HPLC), powder
3-(2-ETHYLPHENOXY)-1-((1S)-1,2,3,4-TETRA-HYDRONAPHTH-1-YLAMINO)-(2S)-2-PROPANOL OXALATE
(S)-1-(2-Ethylphenoxy)-3-(((S)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)propan-2-ol oxalate
3-(2-Ethylphenoxy)-1-[[(1S)-1,2,3,4-tetrahydronaphth-1-yl]amino]-(2S)-2-propanol oxalate salt
1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE
hyperthermia,adrenoceptor,Adrenergic Receptor,adrenergic,Beta Receptor,inhibit,hypothermia,receptor,Inhibitor,SR59230A,SR-59230A

物理化學(xué)性質(zhì)

儲(chǔ)存條件Store at RT

溶解度二甲基亞砜：>10mg/mL

形態(tài)粉末

顏色白色

InChIKeyXTBQNQMNFXNGLR-MKSBGGEFSA-N

SMILESOC(=O)C(O)=O.CCc1ccccc1OC[C@@H](O)CN[C@H]2CCCc3ccccc23

安全數(shù)據(jù)

安全說(shuō)明22-24/25

WGK Germany3

存儲(chǔ)類(lèi)別11 - Combustible Solids

圖譜信息

1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE(174689-39-5)核磁圖(¹HNMR)

常見(jiàn)問(wèn)題列表

生物活性

SR59230A 是一種血腦屏障穿透性的、有效的 β3-adrenergic receptor 的選擇性拮抗劑，對(duì)β3、β1和β2受體的IC50分別為40 nM、408 nM和648 nM。

靶點(diǎn)

Target	Value
β3-adrenergic receptor (Cell-free assay)	40 nM
β1-adrenergic receptor (Cell-free assay)	408 nM
β2-adrenergic receptor (Cell-free assay)	648 nM

體外研究

SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines.

Cell Viability Assay

Cell Line:	Three different neuroblastoma (NB) cell lines, one murine (Neuro-2A) and two human (SK-N-BE(2), BE(2)C)
Concentration:	100 nM, 1 μM, 5 μM, 10 μM, and 50 μM
Incubation Time:	24 hours
Result:	Reduced cell viability in a dose-dependent manner, with significant effect at a concentration limit over 1?μM for Neuro-2A cells and 5?μM for SK-N-BE(2) and BE(2)C).

體內(nèi)研究

MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA.