177943-33-8
中文名稱
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
英文名稱
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
CAS
177943-33-8
分子式
C9H11ClN2O2
分子量
214.649
MOL 文件
177943-33-8.mol
177943-33-8 結(jié)構(gòu)式
基本信息
中文別名
化合物PF-04859989PF-04859989 鹽酸鹽
化合物PF-04859989,10 MM DMSO 溶液
(S)-3-氨基-1-羥基-3,4-二氫喹啉-2(1H)-酮鹽酸
英文別名
177943-33-8PF04859989 hydrochloride
PF-4859989 hydrochloride
PF-04859989 hydrochloride
PF-04859989 hydrochloride >=98% (HPLC)
(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one
L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
2(1H)-Quinolinone, 3-amino-3,4-dihydro-1-hydroxy-, monohydrochloride, (S)- (9CI)
PF 04859989 hydrochloride - L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
物理化學(xué)性質(zhì)
儲(chǔ)存條件room temp
溶解度在水中的溶解度為20mg/mL，澄清
形態(tài)粉末
顏色白色至米色
水溶解性Water: 22 mg/ml
InChI1S/C9H10N2O2.ClH/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12;/h1-4,7,13H,5,10H2;1H/t7-;/m0./s1
InChIKeyWZOBDOKCHIUXAY-FJXQXJEOSA-N
SMILESN[C@H]1CC2=CC=CC=C2N(O)C1=O.Cl
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-116451 | PF-04859989 hydrochloride | 177943-33-8 | 1 mg | 300元 |
| 2026/06/05 | HY-116451 | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride PF-04859989 hydrochloride | 177943-33-8 | 5mg | 600元 |
| 2026/06/05 | HY-116451 | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride PF-04859989 hydrochloride | 177943-33-8 | 10 mM * 1 mLin DMSO | 660元 |
常見(jiàn)問(wèn)題列表
生物活性
PF-04859989 hydrochloride 是一種可透過(guò)血腦屏障的，不可逆的犬尿氨酸轉(zhuǎn)氨酶 KAT II 抑制劑，對(duì) hKATⅡ 和 rKATⅡ 的 IC50 分別為 23 和 263 nM。PF-04859989 hydrochloride 對(duì) KATⅡ 的選擇性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50 分別為22、11和 >50 μM)。體內(nèi)研究
In vivo pharmacokinetic and efficacy studies in rat show that PF-04859989 is a brain-penetrant, irreversible inhibitor and is capable of reducing brain kynurenic acid by 50% at a dose of 10 mg/kg (sc).
Rats receiving PF-04859989 (5 mg/kg; i.p.) exhibited a significantly lower number of spontaneously active DA neurons pertrack.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 5 mg/kg |
| Administration: | I.p. |
| Result: | Exhibited a significantly lower number of spontaneously active dopamine (DA) neurons pertrack compared to controls. |