178908-09-3
中文名稱
178908-09-3
英文名稱
UK-240455
CAS
178908-09-3
分子式
C11H11Cl2N3O5S
分子量
368.19
MOL 文件
178908-09-3.mol
178908-09-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13248 英文別名
UK-240455Methanesulfonamide, N-(6,7-dichloro-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)-N-(2-hydroxyethyl)-
物理化學(xué)性質(zhì)
密度1.686±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)7.96±0.20(Predicted)
178908-09-3價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-19391 | UK-240455 | 178908-09-3 | 1 mg | 3995元 |
常見問(wèn)題列表
生物活性
UK-240455 是一個(gè)有效且有選擇性的 N-甲基 D-天冬氨酸 (NMDA) 甘氨酸位點(diǎn)上的拮抗劑。靶點(diǎn)
NMDA
體內(nèi)研究
UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist. Following i.v. administration of UK-240455 to male rats, UK-240455 has a clearance of 12 mL/min/kg and a volume of distribution of 0.4 L/kg. The plasma concentration of UK-240455 decreases with an apparent half-life of 0.4 h. Analysis of urine (0 to 24 h) for unchanged UK-240455 indicates that 57% of the dose administered is excreted unchanged in the urine. The urinary clearance of UK-240455 in the rat is therefore 7 mL/min/kg. Following oral administration of UK-240455 to male rats, the apparent elimination half-life of UK-240455 from plasma following oral administration is 1.6 h.