178908-09-3
中文名稱
178908-09-3
英文名稱
UK-240455
CAS
178908-09-3
分子式
C11H11Cl2N3O5S
分子量
368.19
MOL 文件
178908-09-3.mol
178908-09-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13248 英文別名
UK-240455Methanesulfonamide, N-(6,7-dichloro-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)-N-(2-hydroxyethyl)-
常見問題列表
生物活性
UK-240455 是一個有效且有選擇性的 N-甲基 D-天冬氨酸 (NMDA) 甘氨酸位點上的拮抗劑。靶點
NMDA
體內(nèi)研究
UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist. Following i.v. administration of UK-240455 to male rats, UK-240455 has a clearance of 12 mL/min/kg and a volume of distribution of 0.4 L/kg. The plasma concentration of UK-240455 decreases with an apparent half-life of 0.4 h. Analysis of urine (0 to 24 h) for unchanged UK-240455 indicates that 57% of the dose administered is excreted unchanged in the urine. The urinary clearance of UK-240455 in the rat is therefore 7 mL/min/kg. Following oral administration of UK-240455 to male rats, the apparent elimination half-life of UK-240455 from plasma following oral administration is 1.6 h.