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17974-57-1

中文名稱 β-Apo-13-carotenone
英文名稱 β-Apo-13-carotenone
CAS 17974-57-1
分子式 C18H26O
分子量 258.4
MOL 文件 17974-57-1.mol
更新日期 2024/12/03 15:40:35
17974-57-1 結(jié)構(gòu)式 17974-57-1 結(jié)構(gòu)式

基本信息

中文別名
Β-APO-13-CAROTENONE
英文別名
D'Orenone
β-Apo-13-carotenone
3,5,7-Octatrien-2-one, 6-methyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (3E,5E,7E)-

物理化學(xué)性質(zhì)

沸點(diǎn)120 °C(Press: 0.0004 Torr)
密度0.945±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 33.33 mg/mL (128.99 mM);Water : < 0.1 mg/mL (insoluble)
形態(tài)Oil
顏色Light yellow to yellow
β-Apo-13-carotenone價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-101953β-Apo-13-carotenone17974-57-11 mg1280元
2026/06/05HY-101953β-Apo-13-carotenone
β-Apo-13-carotenone
17974-57-15mg3200元
2026/06/05HY-101953β-Apo-13-carotenone
β-Apo-13-carotenone
17974-57-110 mM * 1 mLin DMSO3520元

常見(jiàn)問(wèn)題列表

生物活性
β-Apo-13-carotenone (D'Orenone) 是天然存在的β-阿法菌素,是RXRα的拮抗劑。
體外研究

β-apo-13-Carotenone is identified as enzymatic cleavage products of β-carotene in homogenates of intestinal mucosa of rat. β-apo-13-carotenone is found to antagonize the activation of RXRα by 9-cis-retinoic acid and is effective at concentrations as low as 1nM. Molecular modeling studies reveal that β-apo-13-carotenone makes molecular interactions like an antagonist of RXRα. β-apo-13-carotenone competes for 9cRA binding to RXRα with an affinity (7–8 nM) identical to 9cRA itself. β-apo-13-carotenone antagonizes 9cRA activation of full-length hRXRα with a similar efficiency as the known antagonist UVI3003. β-apo-13-carotenone induces formation of the RXRα transcriptionally silent tetramer but does not inhibit coactivator recruitment to the isolated LBD. The uptake and/or metabolism of β-apo-13-carotenone does not allow for accumulation of these β-carotene metabolites in cells. 3T3-L1 adipocyte marker gene expression is induced by β-apo-carotenoid treatment.

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