1800487-55-1
1800487-55-1 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)670.3±55.0 °C(Predicted)
密度1.31±0.1 g/cm3(Predicted)
溶解度DMSO: Soluble
Methanol: Soluble
Methanol: Soluble
酸度系數(shù)(pKa)14.46±0.46(Predicted)
形態(tài)Solid
顏色White to light yellow
應(yīng)用領(lǐng)域
用途一
OT-82 is a potent NAMPT Inhibitor that targets the strong dependence of hematological malignancies on NAD biosynthesis. OT-82 showed strong efficacy against hematopoietic malignancies including acute myeloblastic and lymphoblastic adult and pediatric leukemias, erythroleukemia, multiple myeloma, and Burkitt's lymphoma in vitro and in mouse xenograft models.常見問題列表
概述
OT-82 是一種強(qiáng)效、選擇性和具有口服活性的 NAMPT 的抑制劑。OT-82 對造血源細(xì)胞有選擇性毒性，以 NAD+ 依賴方式誘導(dǎo)細(xì)胞死亡。OT-82 是一種很有前途的抗腫瘤試劑 (antineoplastic agent)，用于血液系統(tǒng)惡性腫瘤的研究。