1802977-61-2
中文名稱(chēng)
1802977-61-2
英文名稱(chēng)
GNE-140 (racemate)
CAS
1802977-61-2
分子式
C25H23ClN2O3S2
分子量
499.04
MOL 文件
1802977-61-2.mol
1802977-61-2 結(jié)構(gòu)式
基本信息
中文別名
LDHA抑制劑(GNE-140 RACEMATE)3-((2-氯苯基)硫代)-6-(4-嗎啉代苯基)-6-(噻吩-3-基)哌啶-2,4-二酮
英文別名
GNE-140 (racemate)GNE-140 racemate (GNE 140 racemate
3-((2-chlorophenyl)thio)-6-(4-morpholinophenyl)-6-(thiophen-3-yl)piperidine-2,4-dione
2,4-Piperidinedione, 3-[(2-chlorophenyl)thio]-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-
所屬類(lèi)別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)739.0±60.0 °C(Predicted)
密度1.43±0.1 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMSO : ≥ 34 mg/mL (68.13 mM)
酸度系數(shù)(pKa)9.61±0.70(Predicted)
形態(tài)Solid
顏色White to off-white
GNE140 racemate價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-100742 | 1802977-61-2 GNE-140 racemate | 1802977-61-2 | 1mg | 820元 |
| 2026/06/05 | HY-100742 | 1802977-61-2 GNE-140 racemate | 1802977-61-2 | 5mg | 2000元 |
| 2026/06/05 | HY-100742 | 1802977-61-2 GNE-140 racemate | 1802977-61-2 | 10mM * 1mLin DMSO | 2196元 |
常見(jiàn)問(wèn)題列表
生物活性
GNE-140 racemate 是一種 (R)-GNE-140 和 (S)-GNE-140 的外消旋混合物。GNE-140 racemate 也是一種有效的乳酸脫氫酶 A (LDHA) 抑制劑。靶點(diǎn)
Lactate dehydrogenase A (LDHA)
體外研究
Increased glucose consumption distinguishes cancer cells from normal cells and is known as the “Warburg effect” because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-to-lactate conversion.