1807453-83-3
1807453-83-3 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度DMF: 5 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
形態(tài)結(jié)晶固體
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
ND-336 is a novel highly selective inhibitor of gelatinases (MMP-2 and MMP-9) and MMP-14. ND-336 accelerates diabetic wound healing by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thereby reversing the pathological condition. ND-336 holds considerable promise in healing of diabetic wounds.常見問題列表
概述
ND-336 是基質(zhì)金屬蛋白酶 (MMP)-2、MMP-9 和 MMP-14 的選擇性抑制劑，Ki 分別為 85、150 和 120 nM。ND-336 通過降低炎癥反應(yīng)、促進創(chuàng)面血管生成和再上皮化，促進小鼠糖尿病創(chuàng)面愈合。