1807551-44-5
中文名稱
化合物 T28413
英文名稱
Acetamide, 2-amino-N-[5-[6-chloro-5-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]-3-pyridinyl]-4-methyl-2-thiazolyl]-
CAS
1807551-44-5
分子式
C21H24ClN5O3S2
分子量
494.03
MOL 文件
1807551-44-5.mol
1807551-44-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T28413 英文別名
PI3KD/VIN01PI3KD/V-IN-01
PI3KD/V IN 01
Acetamide, 2-amino-N-[5-[6-chloro-5-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]-3-pyridinyl]-4-methyl-2-thiazolyl]-
應用領(lǐng)域
用途一
PI3KD/V-IN-01 is a highly potent ATP-competitive PI3Kδ/Vps34 dual inhibitor. In cells, PI3KD/V-IN-01 showed 30-300 fold selectivity between PI3Kδ and other class I PI3K isoforms. PI3KD/V-IN-01 exhibited better anti-proliferative activity against AML, CLL and Burkitt lymphoma cell lines than known selective PI3Kδ and Vps34 inhibitors.