1815618-17-7
中文名稱
Cortistatin-29 (rat) (trifluoroacetate salt)
英文名稱
Cortistatin-29 (rat) (trifluoroacetate salt)
CAS
1815618-17-7
分子式
C161H240N46O41S2
分子量
3540.04
MOL 文件
1815618-17-7.mol
更新日期
2026/05/28 07:46:34
1815618-17-7 結(jié)構(gòu)式
基本信息
中文別名
PYRK-29PYR-GLU-ARG-PRO-PRO-LEU-GLN-GLN-PRO-PRO-HIS-ARG-ASP-LYS-LYS-PRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS-OH (DISULFIDE BONDS)
英文別名
Cortistatin-29 (rat) (H-6444.0500)Cortistatin-29 (rat) (trifluoroacetate salt)
物理化學性質(zhì)
密度1.54±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度Water: 1 mg/ml
形態(tài)A lyophilized powder
序列Pyr-Glu-Arg-Pro-Pro-Leu-Gln-Gln-Pro-Pro-His-Arg-Asp-Lys-Lys-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (Disulfide bonds)
應(yīng)用領(lǐng)域
多肽
皮質(zhì)抑素-29(rat)是一種新的生長抑素家族神經(jīng)內(nèi)分泌多肽，在生物體內(nèi)發(fā)揮著調(diào)節(jié)神經(jīng)內(nèi)分泌功能、誘導免疫耐受及抑制炎癥反應(yīng)的作用。它是一條具有環(huán)狀結(jié)構(gòu)的多肽，具有較長時間的生理活性。用途一
Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-5, respectively. Cortistatin-29 is found at similar levels as cortistatin-14 in mouse AtT20 cells but is secreted at a lower level. Cortistatin-29 corresponds to residues 85-112 of the rat peptide sequence.參考質(zhì)量標準
外觀:白色粉末純度(HPLC) ≥98.0%
醋酸根含量5.0%～12.0%
水分含量≤8.0%
肽含量≥80.0%