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182133-27-3

中文名稱 阿佐昔芬鹽酸鹽
英文名稱 ARZOXIFENE HCL
CAS 182133-27-3
分子式 C28H29NO4S.ClH
分子量 512.067
MOL 文件 182133-27-3.mol
182133-27-3 結(jié)構(gòu)式 182133-27-3 結(jié)構(gòu)式

基本信息

中文別名
阿佐昔芬鹽酸鹽
英文別名
Serm 3
Ly 353381
Ly 353381 HCl
ARZOXIFENE HCL
Arzoxifene hydrochloride
NHSNLUIMAQQXGR-UHFFFAOYSA-N
2-(p-Methoxyphenyl)-3-(p-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride
2-(4-Methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride
Benzo(B)thiophene-6-ol, 2-(4-methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)-, hydrochloride

物理化學(xué)性質(zhì)

熔點(diǎn)156-160°
形態(tài)Solid
顏色Off-white to light yellow
阿佐昔芬鹽酸鹽價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2025/12/22HY-13556A阿佐昔芬鹽酸鹽
Arzoxifene hydrochloride
182133-27-31 mg3600元
2024/08/19HY-13556A阿佐昔芬鹽酸鹽
Arzoxifene hydrochloride
182133-27-35 mg9000元
2023/03/20HY-13556A阿佐昔芬鹽酸鹽
Arzoxifene hydrochloride
182133-27-310 mg14400元

常見問題列表

生物活性
Arzoxifene hydrocloride是一種選擇性的雌激素受體 (estrogen receptor) 調(diào)節(jié)劑,它是乳腺和子宮組織中有效的雌激素拮抗劑,同時作為維持骨密度和降低血清膽固醇的雌激素激動劑。
靶點(diǎn)

Estrogen receptor

體外研究

Arzoxifene inhibits cell growth as effectively as the antiestrogen tamoxifen. Northern analysis reveals that arzoxifene exerts a statistically significant inhibition of pS2 and progesterone receptor B mRNA expression. Significant agonistic effect is observed on the antitrypsin mRNA expression. In contrast to estradiol and tamoxifen, arzoxifene does not upregulate cathepsin D mRNA and protein expression.

體內(nèi)研究

Arzoxifene prevents the ovariectomy-induced increase in body weight and serum cholesterol levels of treated rats and lowers them to below sham levels in a dose dependent manner, with maximum efficacy similar to estrogen or raloxifene. Arzoxifene (LY353381.HCl) prevents loss of bone due to ovariectomy with an ED 50 of about 0.01 mg/kg with maximal efficacy observed at 0.1-1 mg/kg/day. Arzoxifene (LY353381.HCl) antagonizes the estrogen-induced elevation in uterine weight down to vehicle-dosed control levels with ED 50 of 0.03 mg/kg/day.

"182133-27-3" 相關(guān)產(chǎn)品信息
628-13-7 593-81-7 590-46-5 593-51-1
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