1821370-28-8
中文名稱
MitoPQ
英文名稱
MitoPQ
CAS
1821370-28-8
分子式
C39H46IN2P+2
分子量
700.69
MOL 文件
1821370-28-8.mol
更新日期
2024/05/27 22:24:16
1821370-28-8 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.33 mg/ml
形態(tài)結(jié)晶固體
顏色Brown to reddish brown
InChIKeyKCPZNXZOMIOVHZ-UHFFFAOYSA-M
SMILES[P+](C1C=CC=CC=1)(C1C=CC=CC=1)(C1C=CC=CC=1)CCCCCCCCCC[N+]1=CC=C(C2=CC=[N+](C)C=C2)C=C1.[I-]
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301+H311-H330-H315-H319-H335-H372-H400-H410
WGK GermanyWGK 3
存儲(chǔ)類別11 - Combustible Solids
應(yīng)用領(lǐng)域
用途一
MitoPQ, also known as MitoParaquat, is a redox cycler. MitoParaquat (MitoPQ) that comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat. MitoPQ accumulates selectively in the mitochondrial matrix driven by the membrane potential. Within the matrix, MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ increased mitochondrial superoxide in isolated mitochondria and cells in culture ~a thousand-fold more effectively than untargeted paraquat. MitoPQ was also more toxic than paraquat in the isolated perfused heart and in Drosophila in vivo. MitoPQ enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo.常見問(wèn)題列表
概述
MitoPQ 是一個(gè)線粒體 (mitochondria) 靶向氧化還原循環(huán)劑。MitoPQ 通過(guò)復(fù)合物 I 黃素位點(diǎn)的氧化還原循環(huán)產(chǎn)生超氧化物，選擇性地增加線粒體內(nèi)超氧化物的產(chǎn)生。MitoPQ 可用于抗氧化研究。