1821387-73-8

中文名稱(chēng) CU-T12-9

英文名稱(chēng) CU-T12-9

CAS 1821387-73-8

分子式 C17H13F3N4O2

分子量 362.31

MOL 文件 1821387-73-8.mol

更新日期 2026/06/01 11:31:41

1821387-73-8 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 圖譜信息 CU-T12-9價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

化合物CU-T12-9

英文別名

CU-T12-9
N-methyl-4-nitro-2-[4-[4-(trifluoromethyl)phenyl]imidazol-1-yl]aniline
Benzenamine, N-methyl-4-nitro-2-[4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-

物理化學(xué)性質(zhì)

沸點(diǎn)524.3±50.0 °C(Predicted)

密度1.39±0.1 g/cm3(Predicted)

儲(chǔ)存條件-20°C儲(chǔ)存

溶解度DMSO: 250 mg/mL (690.02 mM)

酸度系數(shù)(pKa)3.53±0.10(Predicted)

形態(tài)固體

顏色Light yellow to yellow

圖譜信息

CU-T12-9(1821387-73-8)核磁圖(¹HNMR)

CU-T12-9價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱(chēng)	CAS號(hào)	包裝	價(jià)格
2026/03/03	S2979	CU-T12-9 CU-T12-9	1821387-73-8	5mg	2375.1元
2026/03/03	S2979	CU-T12-9	1821387-73-8	10mM (1mL in DMSO)	3513.51元
2026/03/03	S2979	CU-T12-9 CU-T12-9	1821387-73-8	25mg	7125.3元

常見(jiàn)問(wèn)題列表

生物活性

CU-T12-9 是一種特異性 TLR1/2 激動(dòng)劑，EC50 為 52.9 nM。CU-T12-9 既激活先天免疫系統(tǒng)，又激活適應(yīng)性免疫系統(tǒng)。CU-T12-9 選擇性激活 TLR1/2 異二聚體而對(duì) TLR2/6 沒(méi)有作用。CU-T12-9 通過(guò)促進(jìn) TLR1 和 TLR2 二聚而激活 NF-κB 信號(hào)，致使下游 TNF-α，IL-10，和 iNOS 增加，從而提高身體的免疫反應(yīng)。

靶點(diǎn)

TLR2

52.9 nM (EC ₅₀ , in HEK-Blue cells)

TLR1

52.9 nM (EC ₅₀ , in HEK-Blue cells)

體外研究

CU-T12-9 directly targets TLR1/2 to initiate downstream signaling. By binding to both TLR1 and TLR2, CU-T12-9 facilitates the TLR1/2 heterodimeric complex formation, which in turn activates the downstream signaling.
CU-T12-9 activates the TLR1/2 pathway by inducing NF-κB activation to trigger downstream signaling, such as secreted embryonic alkaline phosphatase (SEAP), NO, and TNF-α.
CU-T12-9 (0.39-100 μM; 24 hours) does not produce toxicity up to 100 μM in HEK-Blue hTLR2 and Raw 264.7 cells.
CU-T12-9 up-regulates the mRNA levels of TLR1, TLR2, TNF, IL-10, and iNOS. CU-T12-9 (0.1-10 μM) activates TLR1 mRNA and iNOS mRNA after Raw 264.7 cells are treated for 24 hours. CU-T12-9 (0.1-10 μM) activates TLR2 and IL-10 mRNA after Raw 264.7 cells are treated for 2 hours. CU-T12-9 (0.1-10 μM) activates TNF mRNA after Raw 264.7 cells are treated for 8 hours.

Cell Cytotoxicity Assay

Cell Line:	HEK-Blue hTLR2 and Raw 264.7 macrophage cells
Concentration:	0.39, 0.78, 1.56, 3.125, 6.25, 12.5, 25, 50, and 100 μM
Incubation Time:	24 hours
Result:	No toxicity was seen up to 100 μM.

RT-PCR