183204-74-2
中文名稱
5-氯-6-[(2-亞氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮
英文名稱
5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione,
CAS
183204-74-2
分子式
C9H11ClN4O2
分子量
242.66
MOL 文件
183204-74-2.mol
更新日期
2026/07/19 15:36:45
183204-74-2 結(jié)構(gòu)式
基本信息
中文別名
替吡嘧啶替比拉西
5-氯-6-[(2-亞氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮
英文別名
MA 1 (pharmaceutical)TPI (thymidine phosphorylase inhibitor)
5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione
5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione,
2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-
所屬類別
醫(yī)藥中間體：嘧啶類化合物物理化學(xué)性質(zhì)
密度1.71±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Water: 1 mg/mL (4.12 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
酸度系數(shù)(pKa)7.06±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
抑制劑
鹽酸替吡嘧啶是一種有效的胸苷磷酸化酶抑制劑，當(dāng)與三氟尿苷結(jié)合形成 TAS-102 時(shí)，可防止三氟尿苷快速降解，從而維持活性藥物的足夠血漿水平。生物活性
Tipiracil 是一種胸苷磷酸化酶 (TPase) 抑制劑。靶點(diǎn)
thymidine phosphorylase
體外研究
Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. The combination of Trifluridine and Tipiracil is a new oral treatment for metastatic colorectal cancer. Tipiracil prevents degradation of FTD through a first-pass effect as a thymidine phosphorylase inhibitor.