1834610-73-9
中文名稱
化合物 T28371
英文名稱
Benzenesulfonamide, 3-cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy]-N-1,2,4-thiadiazol-5-yl-
CAS
1834610-73-9
分子式
C35H32F3N7O3S2
分子量
719.8
MOL 文件
1834610-73-9.mol
1834610-73-9 結(jié)構(gòu)式
基本信息
中文別名
化合物 T283713-CYANO-4-[2-[2-[(2-PIPERIDIN-4-YLETHYLAMINO)METHYL]PYRIDIN-4-YL]-4-[3-(TRIFLUOROMETHYL)PHENYL]PHENO
英文別名
PF6456384PF-6456384
PF06456384
PF 6456384
PF 06456384
PF-06456384
3-cyano-4-[2-[2-[(2-piperidin-4-ylethylamino)methyl]pyridin-4-yl]-4-[3-(trifluoromethyl)phenyl]phenoxy]-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
Benzenesulfonamide, 3-cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy]-N-1,2,4-thiadiazol-5-yl-
物理化學(xué)性質(zhì)
沸點789.8±70.0 °C(Predicted)
密度1.46±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)3.30±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
PF-06456384 is a highly potent and selective NaV1.7 inhibitor (IC50 NaV1.7 = 0.01 nM). PF-06456384 ultimately showed a lack of preclinical efficacy in a mouse formalin pain model and was not progressed further. PF-06456384 may be used to illustrate the potential to support further in vitro and in vivo evaluation of the translation of NaV1.7 inhibition to the treatment of pain.