一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>1852-38-6

1852-38-6

中文名稱 PREGNENOLONE MONOSULFATE SODIUM SALT
英文名稱 PREGNENOLONE SULFATE SODIUM SALT
CAS 1852-38-6
分子式 C21H31NaO5S
分子量 418.52
MOL 文件 1852-38-6.mol
更新日期 2025/09/19 11:23:09
1852-38-6 結(jié)構(gòu)式 1852-38-6 結(jié)構(gòu)式

基本信息

中文別名
孕烯醇酮 硫酸鈉鹽
未標記的孕烯醇硫酸鹽
孕烯醇硫酸鹽 (20,21-13C2,99%
英文別名
Pregnenolone 3-Sulfate
PREGNENOLONE SULFATE SODIUM
SodiuM Pregnenolone-d4 Sulfate
5-Pregnen-3β-ol-20-one sulfate
Pregnenolone sulphate Na+ salt
PREGNENOLONE SULFATE SODIUM SALT
PREGNENOLONE SULPHATE, SODIUM SALT
Pregnenolone-3-sulfate SodiuM Salt
3-Hydroxypregn-5-en-20-one sulfate
Pregnenolone monosulfate sodium salt

物理化學性質(zhì)

熔點192 °C(lit.)
熔點192 °C(lit.)
儲存條件-20°C儲存
溶解度methanol and water: 1.93 mg/mL
溶解度溶于甲醇和水的混溶液中,1.93mg/mL
形態(tài)結(jié)晶固體
顏色White to off-white
InChIKeyABFNHVDDMHKJKK-WRHGONFGSA-N
SMILES[Na].[H][C@@]12CC=C3C[C@H](CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O)OS(O)(=O)=O

安全數(shù)據(jù)

WGK Germany3
WGK Germany3
存儲類別11 - Combustible Solids
PREGNENOLONE MONOSULFATE SODIUM SALT價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/12/22HY-110189PREGNENOLONE MONOSULFATE SODIUM SALT
Pregnenolone monosulfate sodium salt
1852-38-65mg550元
2025/12/22HY-110189PREGNENOLONE MONOSULFATE SODIUM SALT
Pregnenolone monosulfate sodium
1852-38-610 mM * 1 mLin DMSO605元
2025/12/22HY-110189PREGNENOLONE MONOSULFATE SODIUM SALT
Pregnenolone monosulfate sodium salt
1852-38-610mg825元

常見問題列表

生物活性
Pregnenolone monosulfate sodium salt (3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt) 是一種功能強大的神經(jīng)甾體,是包括甾體酮在內(nèi)的各種甾體激素的主要前體。Pregnenolone monosulfate sodium salt 是大麻素 CB1 受體的信號傳導特異性抑制劑,抑制由 CB1 受體介導的四氫大麻酚 (THC) 的作用。Pregnenolone monosulfate sodium salt 可以保護大腦免受大麻毒性的侵襲。
靶點

CB1

Human Endogenous Metabolite

體外研究

CB1 receptor stimulation increases brain Pregnenolone levels, which in turn exerts a negative feedback on the activity of the CB1 receptor antagonizing most of the known behavioral and somatic effects of THC. Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy.
The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC).

體內(nèi)研究

Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se . Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule.

"1852-38-6" 相關產(chǎn)品信息
1485492-21-4 61574-54-7 145-13-1
米脂县| 农安县| 康保县| 新乡县| 蒲江县| 乳山市| 康保县| 宝丰县| 海安县| 原平市| 翁源县| 泊头市| 从化市| 格尔木市| 廉江市| 格尔木市| 瓮安县| 辽阳县| 渝北区| 凉山| 香河县| 万盛区| 黄陵县| 长子县| 巴林右旗| 保康县| 汉寿县| 广东省| 沾化县| 五大连池市| 乌拉特后旗| 乡宁县| 岑巩县| 项城市| 巴马| 桦南县| 米泉市| 嵊泗县| 八宿县| 龙口市| 策勒县|