1883545-50-3
中文名稱
AEG40730 HCL
英文名稱
INDEX NAME NOT YET ASSIGNED
CAS
1883545-50-3
分子式
C52H69ClF6N8O8
分子量
1083.61
MOL 文件
1883545-50-3.mol
1883545-50-3 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
AEG40730 is a potent and selective IAP antagonist and a BIR-binding tetrapeptide. AEG40730 binds to cIAP1 and cIAP2, facilitates their autoubiquitination and proteosomal degradation, and causes a dramatic reduction in RIP1 ubiquitination. Treatment with nanomolar concentrations of AEG40730 resulted in the loss of both XIAP and c-IAP1 proteins, albeit with different kinetics.