1884578-27-1
中文名稱
N-[(2-丙烯-1-基氧基)羰基]-L-纈氨酸-N-[4-[[(4-硝基苯氧基)羰基]氧基]甲基]苯基]-L-丙氨酸酰胺
英文名稱
Alloc-Val-Ala-PAB-PNP
CAS
1884578-27-1
分子式
C26H30N4O9
分子量
542.54
MOL 文件
1884578-27-1.mol
1884578-27-1 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點799.1±60.0 °C(Predicted)
密度1.296±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)11.52±0.46(Predicted)
應(yīng)用領(lǐng)域
用途一
Alloc-Val-Ala-PAB-PNP is a peptide linker with a terminal 4-Nitrophenol group and an Alloc protecting group. The peptide chain can act as a cleavable linker in drug design, such as in antibody drug conjugates (ADC). In peptide synthesis, carboxylate ester derivatives of 4-nitrophenol may serve as activated components for construction of amide moieties. The Alloc group is stable to treatment with piperidine and TFA, and can be removed in neutral conditions with catalytic amounts of Pd(PPh3)4 in the presence of PhSiH3. This allows the allyl system to work orthogonality with the most common protecting groups.