一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁(yè)>CAS數(shù)據(jù)庫(kù)列表>189388-22-5

189388-22-5

中文名稱(chēng) TYR-PRO-TRP-PHE-NH2
英文名稱(chēng) ENDOMORPHIN-1
CAS 189388-22-5
分子式 C34H38N6O5
MDL 編號(hào) MFCD01321063
分子量 610.7
MOL 文件 189388-22-5.mol
更新日期 2026/07/23 09:59:41
189388-22-5 結(jié)構(gòu)式 189388-22-5 結(jié)構(gòu)式

基本信息

中文別名
內(nèi)嗎啡 1
內(nèi)嗎啡肽 1
英文別名
ENDOMORPHIN-1

物理化學(xué)性質(zhì)

熔點(diǎn)144-146℃
沸點(diǎn)1052.8±65.0 °C(Predicted)
密度1.343±0.06 g/cm3(Predicted)
RTECS號(hào)SQ7316800
儲(chǔ)存條件−20°C
儲(chǔ)存條件−20°C
溶解度≥14.9 mg/mL in H2O; ≥30.55 mg/mL in DMSO; ≥47 mg/mL in EtOH
酸度系數(shù)(pKa)9.86±0.15(Predicted)
形態(tài)固體
顏色白色至灰白色
水溶解性溶于水
序列Tyr-Pro-Trp-Phe-NH2
CAS 數(shù)據(jù)庫(kù)189388-22-5(CAS DataBase Reference)

安全數(shù)據(jù)

WGK Germany3
WGK Germany3
存儲(chǔ)類(lèi)別11 - Combustible Solids

知名試劑公司產(chǎn)品信息

TYR-PRO-TRP-PHE-NH2價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2026/06/05HY-P0185TYR-PRO-TRP-PHE-NH2
Endomorphin 1
189388-22-55mg500元
2026/06/05HY-P0185TYR-PRO-TRP-PHE-NH2
Endomorphin 1
189388-22-510mg700元
2026/06/05HY-P0185TYR-PRO-TRP-PHE-NH2
Endomorphin 1
189388-22-525mg1400元

常見(jiàn)問(wèn)題列表

生物活性
Endomorphin 1,一種高度選擇性的高親和力μ-opioid受體激動(dòng)劑 , 對(duì)kappa3結(jié)合位點(diǎn)具有高親和力 ,Ki為 20 到 30 nM 之間。
靶點(diǎn)

Ki: 20-30 nM (kappa 3 opioid receptor)

體外研究

Endomorphin 1 (EM-1) is an endogenous opioid peptide and one of the two Endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with Endomorphin 2 (EM-2). The two Endomorphins display reasonable affinities for kappa 3 binding sites, with K i values between 20 and 30 nM. Endomorphin 1 and Endomorphin 2 compete both μ 1 and μ 2 receptor sites quite potently. Endomorphins have little appreciable affinity for either delta or kappa 1 binding sites, with K i values greater than 500 nM.

體內(nèi)研究

Both Endomorphin 1 and Endomorphin 2 are potent analgesics with peak effects seen at 10 and 15 min, respectively. All subsequent studies are performed at peak effect. Both compounds are fully active supraspinally and spinally, with no indication of ceiling effects. Endomorphin 1 is significantly more potent spinally than supraspinally and, at the spinal level, it is significantly more potent than Endomorphin 2. The response of both agents are readily reversed by naloxone. β-FNA, a highly selective μ antagonist, effectively reverses the actions of both Endomorphins. Both Endomorphin 1 and Endomorphin 2 display a profile similar to morphine. Neither compound have analgesic activity in CXBK mice at a dose which produced over 70% analgesia in control CD-1 mice.

"189388-22-5" 相關(guān)產(chǎn)品信息
141801-26-5 189388-22-5
湟中县| 鱼台县| 大安市| 游戏| 三穗县| 凤阳县| 黑水县| 肇源县| 巨鹿县| 义乌市| 古丈县| 广南县| 潜江市| 仪陇县| 府谷县| 井陉县| 疏勒县| 涿鹿县| 泽普县| 神农架林区| 乌兰浩特市| 拉孜县| 深水埗区| 华坪县| 方正县| 香格里拉县| 乡宁县| 普洱| 阳城县| 苏尼特左旗| 新绛县| 建水县| 汝阳县| 巴林左旗| 利辛县| 太谷县| 郯城县| 娄烦县| 贵溪市| 晋中市| 大冶市|