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190383-13-2

中文名稱(chēng) H-絲氨酰亮氨酰異亮氨酰甘氨酰賴(lài)氨酰纈氨酰NH2
英文名稱(chēng) H-SER-LEU-ILE-GLY-LYS-VAL-NH2
CAS 190383-13-2
分子式 C28H54N8O7
分子量 614.78
MOL 文件 190383-13-2.mol
更新日期 2026/06/08 20:11:18
190383-13-2 結(jié)構(gòu)式 190383-13-2 結(jié)構(gòu)式

基本信息

中文別名
蛋白酶激活的受體-2,酰胺
H-絲氨酰亮氨酰異亮氨酰甘氨酰賴(lài)氨酰纈氨酰NH2
PROTEASE-ACTIVATED RECEPTOR-2, PAR-2 AGONIST, AMIDE肽
英文別名
SLIGKV-NH2
Par-2 Ago
SLIGKVAMIDE
PAR-2 AGONIST AMIDE
PAR2 activating peptide
PAR-2 (1-6) AMIDE (HUMAN)
SER-LEU-ILE-GLY-LYS-VAL-NH2
SER-LEU-ILE-GLY-LYS-VAL-AMIDE
H-SER-LEU-ILE-GLY-LYS-VAL-NH2
H-SER-LEU-ILE-GLY-LYS-VAL-NH2 USP/EP/BP
所屬類(lèi)別
生物化工:多肽

物理化學(xué)性質(zhì)

沸點(diǎn)1030.3±65.0 °C(Predicted)
密度1.161±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度≥13.48 mg/mL in EtOH with gentle warming and ultrasonic; ≥62.9 mg/mL in DMSO; ≥66.2 mg/mL in H2O
酸度系數(shù)(pKa)12.04±0.10(Predicted)
形態(tài)solid
顏色White to off-white
水溶解性Soluble to 1 mg/ml in water
序列H-Ser-Leu-Ile-Gly-Lys-Val-NH2
InChIKeyHOWDUIVVWDUEED-WAUHAFJUSA-N
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

應(yīng)用領(lǐng)域

參考質(zhì)量標(biāo)準(zhǔn)
外觀(guān):白色粉末
純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%

安全數(shù)據(jù)

安全說(shuō)明22-24/25
WGK Germany3
WGK Germany3
存儲(chǔ)類(lèi)別11 - Combustible Solids
H-絲氨酰亮氨酰異亮氨酰甘氨酰賴(lài)氨酰纈氨酰NH2價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2026/06/05HY-P0283H-絲氨酰亮氨酰異亮氨酰甘氨酰賴(lài)氨酰纈氨酰NH2
Protease-Activated Receptor-2, amide
190383-13-21 mg350元
2026/06/05HY-P0283H-絲氨酰亮氨酰異亮氨酰甘氨酰賴(lài)氨酰纈氨酰NH2
Protease-Activated Receptor-2, amide
190383-13-25 mg700元
2026/06/05HY-P0283H-絲氨酰亮氨酰異亮氨酰甘氨酰賴(lài)氨酰纈氨酰NH2
Protease-Activated Receptor-2, amide
190383-13-210 mg1200元

常見(jiàn)問(wèn)題列表

生物活性
Protease-Activated Receptor-2, amide (SLIGKV-NH2) 是一種高效的蛋白酶活化受體-2 (PAR2) 活化肽。
靶點(diǎn)

PAR2

體外研究

The PAR2-activating peptides used are: SLIGKV-OH, SLIGRL-OH, SLIGKV-NH 2 , SLIGRL-NH 2 . The synthetic agonist peptides mimicking the tethered ligand of PAR2, Ser-Leu-Ile-Gly-Lys-Val (SLIGKV-OH), Ser-Leu-Ile-Gly-Arg-Leu (SLIGRL-OH) and their amidated forms Ser-Leu-Ile-Gly-Lys-Val-amide (SLIGKV-NH 2 ) Ser-Leu-Ile-Gly-Arg-Leu-amide (SLIGRL-NH 2 ) have also been demonstrated being able to activate the receptor without enzymatic cleavage, therefore, have been utilised as biological tools to examine physiological functions of PAR2. Protease-Activated Receptor-2, amide is one of a four family subgroup of G-protein-coupled receptors (GPCRs), called PARs. Protease-activated receptors are distinguished from other GPCRs through their unique proteolytic mechanism of activation. For PAR2, activating proteases, such as trypsin, tryptase and coagulation factors VIIa and Xa, cleave a specific extracellular amino-terminal domain of the receptor to reveal a "tethered ligand", SLIGKV- and SLIGRL- for human and mouse/rat PAR2, respectively, which subsequently interacts with the activation domain of the receptor, initiating intracellular signaling pathways. The protease-activated receptor-2 (PAR2) has been implicated in the pathogenesis of several inflammatory and autoimmune disorders, and is expressed in a wide variety of human tissues and cells. PAR2 belongs to a family of seven transmembrane domain receptor proteins that are activated by proteolysis. Enzymatic digestion exposes an N-terminus ligand sequence that binds intramolecularly to the activation site on the extracellular loop II, initiating a G-protein-mediated cell-signalling cascade and nuclear factor-kappa B (NF-κB)-regulated gene transcription.

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