1906920-28-2
中文名稱
化合物 T26744
英文名稱
BAY-598 R-isomer
CAS
1906920-28-2
分子式
C22H20Cl2F2N6O3
分子量
525.34
MOL 文件
1906920-28-2.mol
1906920-28-2 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
BAY-598 R-isomer is the R-isomer of BAY589. BAY-598 R-isomer may be used as a reference compound. BAY-598 is a potent, peptide-competitive chemical probe for SMYD2. BAY-598 has a unique chemotype relative to the current SMYD2 chemical probe LLY-507. BAY-598 inhibits in vitro methylation of p53K370 with IC50 = 27 nM and has more than 100-fold selectivity over other histone methyltransferases and other non-epigenetic targets. BAY-598 inhibits the methylation of p53K370 in cells with IC50 < 1 μM. (Further to this, BAY-598 has properties that are compatible with in vivo experiments.) A control compound, BAY-369, has also been developed. BAY-369 inhibits the in vitro methylation of p53K370 with IC50 > 70 micromolar.