1917306-14-9
中文名稱
化合物 JNJ-61803534
英文名稱
2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-
CAS
1917306-14-9
分子式
C23H23Cl2F6N3O4S
分子量
622.41
MOL 文件
1917306-14-9.mol
1917306-14-9 結(jié)構(gòu)式
基本信息
中文別名
化合物 JNJ-61803534 英文別名
tert-butyl (3R4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate
2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-
物理化學性質(zhì)
密度1.494±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)4.85±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
應用領(lǐng)域
用途一
JNJ-61803534 is a novel potent RORγt inverse agonist, selectively inhibiting RORγt-driven transcription versus closely-related family members, RORα and RORβ, also inhibiting IL-17A production in human CD4+ T cells under Th17 differentiation conditions, but not inhibiting IFNγ production under Th1 differentiation conditions, and having neither impact on in vitro differentiation of regulatory T cells (Treg), nor on the suppressive activity of natural Tregs.