1927857-55-3
中文名稱
化合物 PQR514
英文名稱
2-Pyrimidinamine, 4-(difluoromethyl)-5-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-
CAS
1927857-55-3
分子式
C16H20F2N8O2
分子量
394.38
MOL 文件
1927857-55-3.mol
1927857-55-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 PQR514 英文別名
2-Pyrimidinamine, 4-(difluoromethyl)-5-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-物理化學(xué)性質(zhì)
沸點700.0±65.0 °C(Predicted)
密度1.420±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)4.80±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
PQR514 is a potent pan-PI3K inhibitor (Ki 110alpha =2.2 nM). PQR514 is a follow-up compound for the phase-II clinical compound PQR309. PQR514 has an improved potency both in vitro and in cellular assays with respect to its predecessor compounds. It shows superiority in the suppression of cancer cell_x000D_
proliferation and demonstrates significant antitumor activity in an OVCAR-3 xenograft model at concentrations approximately eight times lower than PQR309