194098-25-4
中文名稱(chēng)
194098-25-4
英文名稱(chēng)
CP-409092
CAS
194098-25-4
分子式
C17H19N3O2
分子量
297.35
MOL 文件
194098-25-4.mol
更新日期
2024/04/29 22:52:17
194098-25-4 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)475.0±45.0 °C(Predicted)
密度1.283±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 41.67 mg/mL (140.14 mM)
酸度系數(shù)(pKa)13.05±0.70(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
CP-409092 是 GABAA 受體的部分激動(dòng)劑，具有抗焦慮活性。靶點(diǎn)
GABA A receptor
體內(nèi)研究
The pharmacokinetics of CP-409,092 following single intravenous and oral doses of 4 and 15 mg/kg, respectively, are characterized by high clearance of 169+ or -18 mL/min/kg, a volume of distribution of 8.99+ or -1.46 L/kg, and an oral bioavailability of 2.9%+ or -3%. Following oral administration of 100 mg/kg [ 14 C]CP-409,092, the total recovery is 89.1%+ or -3.2% for male rats and 89.3%+ or -0.58% for female rats.