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1950647-99-0

中文名稱 PROPANOIC ACID, 2,2-DIMETHYL-, 1,1′,1′′,1′′′-[[2-(2-THIAZOLYLAMINO)ETHYLIDENE]BIS[PHOSPHINYLIDYNEBIS
英文名稱 Propanoic acid, 2,2-dimethyl-, 1,1′,1′′,1′′′-[[2-(2-thiazolylamino)ethylidene]bis[phosphinylidynebis(oxymethylene)]] ester
CAS 1950647-99-0
分子式 C29H50N2O14P2S
分子量 744.73
MOL 文件 1950647-99-0.mol
1950647-99-0 結(jié)構(gòu)式 1950647-99-0 結(jié)構(gòu)式

基本信息

中文別名
PROPANOIC ACID, 2,2-DIMETHYL-, 1,1′,1′′,1′′′-[[2-(2-THIAZOLYLAMINO)ETHYLIDENE]BIS[PHOSPHINYLIDYNEBIS
英文別名
Propanoic acid, 2,2-dimethyl-, 1,1′,1′′,1′′′-[[2-(2-thiazolylamino)ethylidene]bis[phosphinylidynebis(oxymethylene)]] ester

應(yīng)用領(lǐng)域

用途一
HUN47990 is a bisphosphonate (BP) prodrug with antitumor activity. HUN47990 potently inhibits the in vitro growth of a variety of tumor cell lines, especially hematopoietic cell lines, at nanomolar concentrations. HUN47990 inhibited the prenylation of the RAP1A small GTPase signaling protein at concentrations as low as 1-10 nM. HUN47990 slowed the growth of human bladder cancer cells in an immunodeficient mouse model. HUN47990 is significantly more active than zoledronic acid, the most active FDA-approved BP, and a potential anti-cancer therapeutic. HUN47990 was first reported in ChemMedChem. 2016 Dec 16;11(24):2656-2663 (compound 7). This product has no formal name at the moment.
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