1954650-11-3
中文名稱
化合物 JMS-053
英文名稱
Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-
CAS
1954650-11-3
分子式
C13H8N2O2S
分子量
256.28
MOL 文件
1954650-11-3.mol
1954650-11-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 JMS-053 英文別名
JMS-053Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-
JMS-053 7-Imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione
物理化學(xué)性質(zhì)
密度1.53±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)8.47±0.20(Predicted)
形態(tài)Solid
顏色Light brown to brown
應(yīng)用領(lǐng)域
用途一
JMS-053 is a potent inhibitor of the dual specificity phosphatase PTP4A3 that is potentially suitable for cancer therapy. JMS-053 markedly enhanced microvascular barrier function after exposure of endothelial cells to vascular endothelial growth factor or lipopolysaccharide. JMS-053 also blocked the concomitant increase in RhoA activation and loss of Rac1. In human ovarian cancer cells, JMS-053 impeded migration, disrupted spheroid growth, and decreased RhoA activity. Importantly, JMS-053 displayed anticancer activity in a murine xenograft model of drug resistant human ovarian cancer.