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1957236-36-0

中文名稱 4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
英文名稱 4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
CAS 1957236-36-0
分子式 C21H28N4O4
分子量 400.47
MOL 文件 1957236-36-0.mol
更新日期 2026/05/27 09:48:56
1957236-36-0 結(jié)構(gòu)式 1957236-36-0 結(jié)構(gòu)式

基本信息

中文別名
泊馬度胺-氨基
泊馬度胺-C8-氨基
英文別名
Pomalidomide-NH2
Pomalidomide-C8-NH2
Thalidomide-NH-C8-NH2
4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)amino]-2-(2,6-dioxo-3-piperidinyl)-
4-((8-aminooctyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride

應(yīng)用領(lǐng)域

用途一
Thalidomide-NH-C8-NH2 is a Thalidomide -based cereblon ligand with a linker, which is a useful precursor for synthesis of PROTAC degraders. Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. PROTAC degraders are usually heterobifunctional small molecules consisting of two ligands joined by a linker: one ligand recruits and binds a protein of interest (POI) while the other recruits and binds an E3 ubiquitin ligase. Simultaneous binding of the POI and ligase by the PROTAC induces ubiquitylation of the POI and its subsequent degradation by the ubiquitin–proteasome system (UPS), after which the PROTAC is recycled to target another copy of the POI.

常見問題列表

概述
Thalidomide-NH-C8-NH2 是一種合成的 E3 連接酶配體-linker 偶聯(lián)物,包含基于 Thalidomide 的 cereblon 配體和 1 個(gè) linker,可用于合成 PROTAC。
"1957236-36-0" 相關(guān)產(chǎn)品信息
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