198624-01-0
中文名稱
Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-NH2
英文名稱
Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-NH2
CAS
198624-01-0
分子式
C162H240N40O47S
分子量
3531.95
MOL 文件
198624-01-0.mol
198624-01-0 結(jié)構(gòu)式
基本信息
中文別名
GIP片段多肽1-30 英文別名
GIP (1-30) amide (Human)Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-NH2
L-Lysinamide, L-tyrosyl-L-alanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-isoleucyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-L-alanyl-L-methionyl-L-α-aspartyl-L-lysyl-L-isoleucyl-L-histidyl-L-glutaminyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-asparaginyl-L-tryptophyl-L-leu...
物理化學(xué)性質(zhì)
沸點(diǎn)3054.5±65.0 °C(Predicted)
密度1.329±0.06 g/cm3(Predicted)
序列Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-NH2
常見問題列表
生物活性
GIP (1-30) amide,human 是葡萄糖依賴性促胰島素多肽 (GIP) 片段。葡萄糖依賴性促胰島素多肽是一種腸降血糖素激素，可刺激胰島素分泌并減少餐后血糖波動(dòng)。GIP (1-30) amide,human 在 10-9-10-6 M 范圍內(nèi)劑量依賴性地促進(jìn)胰島素分泌。體外研究
The glucose-dependent action of Glucose-dependent insulinotropic polypeptide (GIP) on pancreatic β-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. In a 50% aqueous trifluoroethanol solvent, GIP(1-30) amide has an α-helical structural region from F6 to A28. The structures calculated for GIP(1-30) amide remain within one family of conformations and the level of agreement between the structures demonstrated the ordered arrangement.