200189-97-5
中文名稱
TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346
英文名稱
N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)aminemaleate
CAS
200189-97-5
分子式
C23H21NO5
分子量
391.42
MOL 文件
200189-97-5.mol
200189-97-5 結(jié)構(gòu)式
基本信息
中文別名
奧米加匹馬來酸鹽 英文別名
CGP3466BCGP-3466B
TCH 346 maleate
CGP 3466B maleate
CGP 3466 (maleate)
TCH 346 MALEATE
CGP3466B
CGP-3466B
TCH346
TCH-346
N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)aminemaleate
物理化學(xué)性質(zhì)
儲存條件Store at +4°C
溶解度溶于二甲基亞砜
形態(tài)固體
顏色白色
InChI1S/C19H17NO.C4H4O4/c1-3-12-20(2)14-16-13-15-8-4-6-10-18(15)21-19-11-7-5-9-17(16)19;5-3(6)1-2-4(7)8/h1,4-11,13H,12,14H2,2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKeySQAZQLMBEHYFJA-BTJKTKAUSA-N
SMILESN(CC1=Cc2c(cccc2)Oc3c1cccc3)(CC#C)C.OC(=O)\C=C/C(=O)O
TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-16361A | TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346 Omigapil maleate | 200189-97-5 | 5 mg | 800元 |
| 2026/06/05 | HY-16361A | TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346 Omigapil maleate | 200189-97-5 | 10 mM * 1 mL in DMSO | 880元 |
| 2026/06/05 | HY-16361A | TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346 Omigapil maleate | 200189-97-5 | 10 mg | 1300元 |
常見問題列表
生物活性
Omigapil maleate 是一種具有口服活性的 GAPDH 亞硝基化抑制劑，可消除 Aβ1-42 誘導(dǎo)的小鼠 tau 乙?；?，記憶障礙和運(yùn)動功能障礙，Omigapil maleate 具有研究阿爾茨海默癥的潛力。Omigapil maleate (CGP3446B maleate) 是一種有效的凋亡 (apoptosis) 抑制劑。Omigapil maleate 可用于研究先天性肌營養(yǎng)不良 (CMD)。靶點(diǎn)
Apoptosis
體內(nèi)研究
Treatment of mice with Omigapil (0.1 mg/kg) results in improved muscle regeneration and increased force.
| Animal Model: | 12-week-old dyW/ mag mice |
| Dosage: | 0.1 mg/kg |
| Administration: |
For the first week of drug treatment, administered once daily by intraperitoneal injection.
After weaning (3 weeks of age), applied once daily by oral gavage. |
| Result: |
Reduced the muscle fibre loss.
Many of the functional parameters were significantly improved by omigapil. |