2007955-07-7
中文名稱
(S)-2-((S)-1-AMINO-3-(1H-INDOL-3-YL)-1-OXOPROPAN-2-YLCARBAMOYL)-4-METHYLPENTY((R)-1-AMINO-3-PHENYLPR
英文名稱
(S)-2-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamoyl)-4-methylpenty((R)-1-amino-3-phenylpropyl)phosphinic acid
CAS
2007955-07-7
分子式
C27H37N4O4P
分子量
512.58
MOL 文件
2007955-07-7.mol
2007955-07-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 DG013A((S)-2-(((S)-1-氨基-3-(1H-吲哚-3-基)-1-氧代丙-2-基)氨甲?；?-4-甲基戊基)((R)-1-氨基-3-苯丙基)次膦酸
英文別名
(S)-2-((S)-1-AMINO-3-(1H-INDOL-3-YL)-1-OXOPROPAN-2-YLCARBAMOYL)-4-METHYLPENTY((R)-1-AMINO-3-PHENYLPR(S)-2-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamoyl)-4-methylpenty((R)-1-amino-3-phenylpropyl)phosphinic acid
物理化學(xué)性質(zhì)
沸點(diǎn)888.8±65.0 °C(Predicted)
密度1.248±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)2.17±0.50(Predicted)
應(yīng)用領(lǐng)域
用途一
DG013A is a a phosphinic pseudotripeptide and ERAP2 inhibitor with nanomolar potency for ERAP2. A crystal structure of a phosphinic pseudotripeptide (DG013A) bound into the active site of ERAP2 revealed five distinct protein elements that were hypothesized to drive inhibitor potency.