2054938-28-0
英文名稱
2,5-Piperazinedione, 3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene-d]-6-(phenylmethylene)-, (3Z,6Z)-
CAS
2054938-28-0
分子式
C19H20N4O2
分子量
336.4
MOL 文件
2054938-28-0.mol
2054938-28-0 結(jié)構(gòu)式
基本信息
英文別名
MBRI-001MBRI 001
NPI-2358-d
plinabulin-d
MBRI001. BPI-2358-d
2,5-Piperazinedione, 3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene-d]-6-(phenylmethylene)-, (3Z,6Z)-
應用領(lǐng)域
用途一
MBRI-001 is a deuterium-substituted plinabulin derivative as a potent anti-cancer agent. MBRI-001 exhibited better pharmacokinetic characteristics than that of plinabulin. Additionally, its antitumor activity is in a low nanomolar level for a variety of cancer cell lines and high activity against human NCI-H460 xenograted in mice intravenous administration. Importantly, continuous administration of MBRI-001 exhibited lower toxicity compared to docetaxel.