2056262-08-7
2056262-08-7 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)529.3±50.0 °C(Predicted)
密度1.15±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)15.22±0.60(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
應(yīng)用領(lǐng)域
用途一
BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. It displays 14-fold selectivity for GSK3β. BRD3731 displays reduced potency towards the GSK3β (D133E), with an IC50 = 53 nM compared to GSK3β (wt) (cf. IC50 = 15 nM). Moreover, BRD3731 inhibits GSK3β with a Kd of 3.3 μM in cellular context. In addition, BRD3731 is a GSK3β- selective inhibitor from patent US20160375006A1, compound example 272.常見問題列表
概述
(R)-BRD3731 是一種 GSK3 的抑制劑，對(duì) GSK3β 和 GSK3α 的 IC50 值分別為 1.05 和 6.7 μM。詳細(xì)信息請(qǐng)參考專利文獻(xiàn) US20160375006A1 中的化合物 273。