205640-91-1

中文名稱食欲肽B (人)

英文名稱 OREXIN B (HUMAN)

CAS 205640-91-1

分子式 C123H212N44O35S

分子量 2899.34

MOL 文件 205640-91-1.mol

更新日期 2026/06/10 08:20:38

205640-91-1 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 應(yīng)用領(lǐng)域安全數(shù)據(jù) 常見問題列表

基本信息

中文別名

食欲肽B (人)
人OREXIN B
食欲肽B(人) ≥98%
食欲肽B(人) ≥98%, ≥98% (HPLC)

英文別名

HYPOCRETIN-2
Human orexin B
OREXIN B (HUMAN)
HYPOCRETIN-2, HUMAN
OREXIN B HUMAN ≥98%
PubChem ID: 90479794
OREXINS OREXIN B HUMAN
OREXIN B (HUMAN) USP/EP/BP
Orexin B (human), ≥98% (HPLC)
RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2

所屬類別

生物化工：多肽

物理化學(xué)性質(zhì)

密度1.49±0.1 g/cm3(Predicted)

儲(chǔ)存條件-20°C

形態(tài)lyophilized

水溶解性Soluble to 1 mg/ml in Water

序列H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

應(yīng)用領(lǐng)域

參考質(zhì)量標(biāo)準(zhǔn)

外觀:白色粉末
純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%

安全數(shù)據(jù)

WGK Germany3

海關(guān)編碼2937190000

存儲(chǔ)類別11 - Combustible Solids

常見問題列表

生物活性

Orexin B, human是 Orexin 受體的內(nèi)源性激動(dòng)劑，與OX1和OX2結(jié)合的 Ki 值分別為 420 和 36 nM。

靶點(diǎn)

Ki: 420 nM (OX1), 36 nM (OX2)

體外研究

Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC ₅₀ of 36 nM in the binding assay and an EC ₅₀ of 60 nM in the [Ca ²⁺ ]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC ₅₀ in the competitive binding assay and the EC ₅₀ in the [Ca ²⁺ ]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.

體內(nèi)研究