205654-37-1
中文名稱
205654-37-1
英文名稱
Urea, N'-[[2-[2-[(4-chlorophenyl)thio]ethoxy]-3-methoxy-5-[(2S,5S)-tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]methyl]-N-hydroxy-N-methyl-
CAS
205654-37-1
分子式
C31H37ClN2O8S
分子量
633.15
MOL 文件
205654-37-1.mol
205654-37-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10844 英文別名
Urea, N'-[[2-[2-[(4-chlorophenyl)thio]ethoxy]-3-methoxy-5-[(2S,5S)-tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]methyl]-N-hydroxy-N-methyl-常見問題列表
生物活性
CMI-392是一種雙重 5-lipoxygenese 抑制劑和血小板活化因子 (PAF) 受體拮抗劑，IC50 值分別為100和10 nM。靶點
|
5-LO 100 nM (IC 50 ) |
PAF 10 nM (IC 50 ) |
體內(nèi)研究
Topical treatment of CMI-392 in the acute and chronic TPA models result in a significant decrease of ear weight, inflammatory cell infiltration, and histological examination. The ED 50 for PAF-induced mouse hemoconcentration and arachidonic acid-induced mouse ear edema are 2.2 and 1.8 mg/kg, respectively.