2062200-97-7
2062200-97-7 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
PBS (pH:7.2):10.0(Max Conc. mg/mL);30.66(Max Conc. mM)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-15260A | XL413 HYDROCHLORIDE XL413 monohydrochloride | 2062200-97-7 | 1 mg | 604元 |
| 2026/06/05 | HY-15260A | XL413 HYDROCHLORIDE XL413 monohydrochloride | 2062200-97-7 | 5 mg | 1330元 |
| 2026/06/05 | HY-15260A | XL413 HYDROCHLORIDE XL413 monohydrochloride | 2062200-97-7 | 10 mg | 1860元 |
常見問(wèn)題列表
|
Cdc7 3.4 nM (IC 50 ) |
PIM1 42 nM (IC 50 ) |
CK2 215 nM (IC 50 ) |
XL413 inhibits the cell proliferation (IC 50 = 2685 nM), decreases cell viability (IC 50 = 2142 nM) and elicits the caspase 3/7 activity (EC 50 = 2288 nM) in Colo-205 cells. XL413 also significantly inhibits the anchorage-independent growth of colo-205 in soft agar (IC 50 = 715 nM). XL413 shows cytotoxic effects on tumors, with IC 50 of 22.9 μM in HCC1954 cells and 1.1 μM in Colo-205 cells. XL413 induces apoptosis in the Colo-205 cells, but not in HCC1954 cells. XL413 is effective DDK inhibitors in vitro, with IC 50 of 22.7 nM. XL413 is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells.
XL413 (100 mg/kg, p.o.) shows excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) is well tolerated at all the doses, with no significant body weight loss.