207572-68-7
中文名稱
RILMENIDINE HEMIFUMARATE SALT
英文名稱
RILMENIDINE HEMIFUMARATE SALT
CAS
207572-68-7
分子式
2C10H16N2O.C4H4O4
分子量
476.57
MOL 文件
207572-68-7.mol
更新日期
2026/03/06 10:49:53
207572-68-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T21911 英文別名
LZFATBMLSYHRTC-WXXKFALUSA-NRILMENIDINE HEMIFUMARATE SALT
n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt
Oxaminozoline hemifumarate salt, Rilmenidene hemifumarate salt, N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度二甲基亞砜：>10mg/mL
形態(tài)固體
顏色白色
InChI1S/2C10H16N2O.C4H4O4/c2*1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10;5-3(6)1-2-4(7)8/h2*7-9H,1-6H2,(H,11,12);1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChIKeyLZFATBMLSYHRTC-WXXKFALUSA-N
SMILESOC(=O)\C=C\C(O)=O.C1CN=C(NC(C2CC2)C3CC3)O1.C4CN=C(NC(C5CC5)C6CC6)O4
RILMENIDINE HEMIFUMARATE SALT價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-100490AR | RILMENIDINE HEMIFUMARATE SALT Rilmenidine hemifumarate (Standard) | 207572-68-7 | 5 mg | 1912元 |
| 2026/06/05 | HY-100490AR | RILMENIDINE HEMIFUMARATE SALT Rilmenidine hemifumarate (Standard) | 207572-68-7 | 10 mg | 3060元 |
| 2026/06/05 | HY-100490AR | RILMENIDINE HEMIFUMARATE SALT Rilmenidine hemifumarate (Standard) | 207572-68-7 | 25 mg | 6125元 |
常見問題列表
生物活性
Rilmenidine hemifumarate 是一種新型的抗高血壓藥物和口服活性選擇性 I1 咪唑啉受體 (I1 imidazoline receptor) 激動(dòng)劑。Rilmenidine hemifumarate 也是一種 α2 腎上腺素受體激動(dòng)劑。Rilmenidine phosphate 誘導(dǎo)自噬 (autophagy)。Rilmenidine hemifumarate 可通過減少交感神經(jīng)過度活躍而發(fā)揮中樞作用，并通過抑制 Na+/H+ 反向轉(zhuǎn)運(yùn)而在腎臟中發(fā)揮作用。Rilmenidine hemifumarate可調(diào)節(jié)白血病細(xì)胞增殖，刺激促凋亡蛋白 Bax，從而誘導(dǎo)人白血病 K562 細(xì)胞線粒體通路的紊亂和凋亡。體外研究
Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors.
Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation.
Cell Viability Assay
| Cell Line: | K562 cells |
| Concentration: | 25, 50, 100 μM |
| Incubation Time: | 24 hours |
| Result: | Dose-dependently inhibited K562 colony formation. |
體內(nèi)研究
Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age.
Rilmenidine decreases levels of mutant huntingtin.