207678-81-7
中文名稱
HS014
英文名稱
HS014
CAS
207678-81-7
分子式
C71H94N20O17S2
分子量
1563.76
MOL 文件
207678-81-7.mol
更新日期
2026/07/07 17:20:45
207678-81-7 結(jié)構(gòu)式
基本信息
中文別名
N-乙酰基-L-半胱氨酰-L-A-谷氨酰-L-組氨酰-3-(2-萘基)-D-丙氨酰-L-精氨酰-L-色氨酰甘氨酰-L-半胱氨酰-L-脯氨酰-L-脯氨酰-L-賴氨酰-L-A-天冬氨酰胺環(huán)(1->8)-二硫醚 英文別名
HS014mc4receptor antagonist
M.W. 1563.77 C71H94N20O17S2
Melanocortin 4 Receptor antagonist
(AC-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE
Acetyl-(Cys11,D-2-Nal14,Cys18)-b-MSH (11-22) aMide
Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide
(ACETYL-CYS11-BETA-(2-NAPHTHYL)*-D-ALA14,CYS18)-BET
Acetyl-(Cys11,D-2-Nal14,Cys18)-Beta-MSH (11-22) amide
Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) aMide HS014
物理化學(xué)性質(zhì)
密度1.57±0.1 g/cm3(Predicted)
儲(chǔ)存條件−20°C
儲(chǔ)存條件−20°C
酸度系數(shù)(pKa)4.07±0.10(Predicted)
形態(tài)solid
水溶解性Soluble to 1 mg/ml in water
序列Ac-Cys-Glu-His-{D-2Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Cys1-Cys8)
HS014價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2023/03/20 | HY-P1216 | HS014 HS014 | 207678-81-7 | 1 mg | 4500元 |
| 2023/03/20 | HY-P1216 | HS014 HS014 | 207678-81-7 | 5 mg | 13500元 |
常見問題列表
生物活性
HS014 是一種高效、選擇性的黑素皮質(zhì)素-4 (MC4) 受體拮抗劑，對(duì)人 MC4、MC1、MC3 和 MC5 受體的 Ki 值分別為 3.16、108、54.4 和 694 nM。HS014 調(diào)節(jié)嗎啡對(duì)小鼠行為的影響。HS014 增加自由喂養(yǎng)大鼠的食物攝取量。體內(nèi)研究
The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively.
Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate.