208109-38-0
中文名稱
F 13714
英文名稱
Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]-
CAS
208109-38-0
分子式
C21H25ClF2N4O
分子量
422.9
MOL 文件
208109-38-0.mol
208109-38-0 結(jié)構(gòu)式
基本信息
中文別名
F 13714 英文別名
Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[[5-methyl-6-(methylamino)-2-pyridinyl]methyl]amino]methyl]-1-piperidinyl]-物理化學(xué)性質(zhì)
沸點(diǎn)583.8±50.0 °C(Predicted)
密度1.29±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度DMSO: 2mg/mL, clear
酸度系數(shù)(pKa)7.97±0.20(Predicted)
形態(tài)powder
顏色white to beige
應(yīng)用領(lǐng)域
用途一
F13714 is a Serotonin 5-HT1A Receptor Agonist. F13714 shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress. F13714 has a high affinity (0.1 nM) and selectivity for 5-HT(1A) receptors. In vitro (18)F-F13714 binding in rats was consistent with the known 5-HT(1A) receptors distribution (hippocampus and cortical areas) and was particularly high in the dorsal raphe. In vitro binding of (18)F-F13714 was blocked in a dose-dependent fashion by WAY100635, the prototypical 5-HT(1A) antagonist, and by the endogenous agonist, serotonin (5-HT). Addition of Gpp(NH)p also inhibited in vitro (18)F-F13714 binding, consistent with a preferential binding of the compound to G-protein-coupled receptors. Ex vivo tissue measurements in rat revealed an absence of brain radioactive metabolites.