2088001-24-3
中文名稱
(S)-benzyl (6-acrylamido-1-(4-(7-hydroxy-2-oxo-2H-chromene-3-carbonyl)piperazin-1-yl)-1-oxohexan-2-yl)carbamate
英文名稱
(S)-benzyl (6-acrylamido-1-(4-(7-hydroxy-2-oxo-2H-chromene-3-carbonyl)piperazin-1-yl)-1-oxohexan-2-yl)carbamate
CAS
2088001-24-3
分子式
C31H34N4O8
分子量
590.62
MOL 文件
2088001-24-3.mol
2088001-24-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T29086 英文別名
151142VA5 TG2 inhibitor
(S)-benzyl (6-acrylamido-1-(4-(7-hydroxy-2-oxo-2H-chromene-3-carbonyl)piperazin-1-yl)-1-oxohexan-2-yl)carbamate
物理化學(xué)性質(zhì)
沸點(diǎn)955.8±65.0 °C(Predicted)
密度1.331±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)7.68±0.20(Predicted)
應(yīng)用領(lǐng)域
用途一
VA5 inhibits both transamidase and GTP-binding activities. Transamidase activity is inhibited by direct inhibitor binding at the transamidase site, and GTP binding is blocked because inhibitor interaction at the transamidase site locks the protein in the extended/open conformation to disorganize/inactivate the GTP binding/GTPase site.