2089617-83-2
2089617-83-2 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點562.0±60.0 °C(Predicted)
密度1.137±0.06 g/cm3(Predicted)
儲存條件2-8°C
溶解度DMSO: 2mg/mL, clear (warmed)
酸度系數(shù)(pKa)8.66±0.10(Predicted)
形態(tài)powder
顏色white to beige
InChI1S/C22H35N5O2/c1-5-6-7-8-11-23-22-25-18-15-20(29-4)19(28-3)14-17(18)21(26-22)24-16-9-12-27(2)13-10-16/h14-16H,5-13H2,1-4H3,(H2,23,24,25,26)
InChIKeyZYNUWSFRZCRKSN-UHFFFAOYSA-N
SMILESCN(CC1)CCC1NC2=C3C(C=C(OC)C(OC)=C3)=NC(NCCCCCC)=N2
應(yīng)用領(lǐng)域
用途一
MS012 is a Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. MS012 exhibited stronger binding affinity to GLP (Kd = 46 ± 15 nM) than G9a (Kd = 610 ± 68 nM). MS012 was 13-fold selective for GLP over G9a. G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic domains. GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone substrates.