2093400-18-9
2093400-18-9 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.33±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)7.32±0.50(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
應(yīng)用領(lǐng)域
用途一
OTS186935 is a protein methyltransferase SUV39H2 inhibitor. OTS186935 shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. It regulates the production of γ-H2AX in cancer cells.常見問題列表
概述
OTS186935 是一種有效的蛋白甲基轉(zhuǎn)移酶 SUV39H2 抑制劑，IC50 值為 6.49 nM。OTS186935 對(duì)小鼠異種移植模型的腫瘤生長有明顯的抑制作用，且無明顯毒性。OTS193320 調(diào)節(jié)癌細(xì)胞中 γ-H2AX 的產(chǎn)生。