2093408-03-6
中文名稱(chēng)
AY 254
英文名稱(chēng)
INDEX NAME NOT YET ASSIGNED
CAS
2093408-03-6
分子式
C30H49N9O6
分子量
631.77
MOL 文件
2093408-03-6.mol
2093408-03-6 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.43±0.1 g/cm3(Predicted)
溶解度Soluble to 2 mg/ml in 0.1% acetic acid
酸度系數(shù)(pKa)12.09±0.46(Predicted)
序列{5-Isoxazolylcarbonyl-Cha}-{Chg}-Ala-Arg-NH2
應(yīng)用領(lǐng)域
用途一
AY 254 is a potent PAR2 biased agonist. It selectively activates ERK1/2 signaling (EC50 = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+ release). AY 254 reduces cytokine-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cells in vitro.