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2093416-31-8

中文名稱 4-((2-(2-(2-(2-氨基乙氧基)乙氧基)乙氧基)乙基)氨基)-2-(2,6-二氧代-哌啶-3-基)異吲哚-1,3-二酮
英文名稱 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS 2093416-31-8
分子式 C21H28N4O7
分子量 448.47
MOL 文件 2093416-31-8.mol
2093416-31-8 結(jié)構(gòu)式 2093416-31-8 結(jié)構(gòu)式

基本信息

中文別名
4-((2-(2-(2-(2-氨基乙氧基)乙氧基)乙氧基)乙基)氨基)-2-(2,6-二氧代-哌啶-3-基)異吲哚-1,3-二酮
英文別名
Pomalidomide-PEG3-C2-NH2
Cereblon Ligand-Linker Conjugates 5
E3 ligase Ligand-Linker Conjugates 30
4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
所屬類別
催化劑及助劑:聚合物

物理化學(xué)性質(zhì)

沸點(diǎn)694.2±55.0 °C(Predicted)
密度1.361±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)10.74±0.40(Predicted)

應(yīng)用領(lǐng)域

用途一
Pomalidomide-PEG3-C2-NH2 is a Pomalidomide-based cereblon ligand with a linker, which is a useful precursor for synthesis of PROTAC degraders. Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. PROTAC degraders are usually heterobifunctional small molecules consisting of two ligands joined by a linker: one ligand recruits and binds a protein of interest (POI) while the other recruits and binds an E3 ubiquitin ligase. Simultaneous binding of the POI and ligase by the PROTAC induces ubiquitylation of the POI and its subsequent degradation by the ubiquitin–proteasome system (UPS), after which the PROTAC is recycled to target another copy of the POI.
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